ALTHOUGH IT MAY VARY FROM PATIENT TO PATIENT,

MOST ADULT PATIENTS WITH CHRONIC COUGH HAVE A COMMON CLINICAL PRESENTATION1,2

EXPLORE COMMON CLINICAL PRESENTATIONS OF CHRONIC COUGH1,2

Men and Women Are Affected by Chronic Cough, but Patients Are Typically Females in Their 50s

Men and women are affected, but patients are typically females in their 50s3

Chronic Cough Patients Typically Have a Nonproductive Cough That Can Last for Months or Years

Patients typically have a nonproductive cough that can last for months or years3,4

Cough hypersensitivity is a common characteristic in patients with chronic cough and includes5-7

Allotussia Is a Hypersensitive Response Triggered by Nontussive Stimuli

ALLOTUSSIA is a hypersensitive response triggered by nontussive stimuli not normally sufficient to cause cough, such as cold air, singing or talking, and fatigue or stress5,7

ALLOTUSSIA is a hypersensitive response triggered by nontussive stimuli not normally sufficient to cause cough, such as cold air, singing or talking, and fatigue or stress5-7

Hypertussia Is Another Form of Cough Hypersensitivity, Which Can Be Characterized as a Cough Triggered by Smaller Amounts of Known Cough-Inducing Stimuli

HYPERTUSSIA is another form of cough hypersensitivity, which can be characterized as a cough triggered by smaller amounts of known cough-inducing stimuli5,7

HYPERTUSSIA is another form of cough hypersensitivity, which can be characterized as a cough triggered by smaller amounts of known cough-inducing stimuli5-7

These Responses to Stimuli (Allotussia and Hypertussia) Can Sometimes Trigger an Uncontrollable Bout of Coughing

These responses to stimuli (allotussia and hypertussia) can sometimes trigger an uncontrollable bout of coughing5

These common characteristics in patients with chronic cough suggest that cough could be considered a disease entity, rather than a symptom5,8,9

Studies suggest that patients with refractory chronic cough and unexplained chronic cough exhibit symptoms consistent with cough hypersensitivity10,11

START EXPLORING PATIENT PRESENTATIONS TO REVEAL HYPOTHETICAL CHRONIC COUGH PATIENT PROFILES

Answer the following questions to identify a hypothetical patient presenting with chronic cough (>8 weeks)

Answer the following questions to identify a hypothetical patient presenting with chronic cough (>8 weeks)

1

HAVE YOU IDENTIFIED ANYRED FLAGSOR POTENTIAL CONTRIBUTING FACTORS IN THE PATIENT’S HISTORY?1

(Click on "red flags" to see the list of clues that may indicate a potentially life-threatening condition)

2

AFTER A THOROUGH DIAGNOSTIC WORKUP, HAVE YOU IDENTIFIED ANY UNDERLYING CONDITIONS THAT MAY BE ASSOCIATED WITH CHRONIC COUGH?1

(Asthma, GERD, UACS [postnasal drip], NAEB, or less common conditions)

3

IS THE COUGH IMPROVING AFTER 4-6 WEEKS OF APPROPRIATE TREATMENT FOR THE UNDERLYING CONDITION?1

GERD, gastroesophageal reflux disease; UACS, upper airway cough syndrome; NAEB, nonasthmatic eosinophilic bronchitis.

Hypothetical patient

Hypothetical patient

1

2

3

HAVE YOU IDENTIFIED ANY RED FLAGS OR POTENTIAL CONTRIBUTING FACTORS IN THE PATIENT’S HISTORY?1

(Click on "red flags" to see the list of clues that may indicate a potentially life-threatening condition)

AFTER A THOROUGH DIAGNOSTIC WORKUP, HAVE YOU IDENTIFIED ANY UNDERLYING CONDITIONS THAT MAY BE ASSOCIATED WITH CHRONIC COUGH?1

(Asthma, GERD, UACS [postnasal drip], NAEB, or less common conditions)

IS THE COUGH IMPROVING AFTER 4-6 WEEKS OF APPROPRIATE TREATMENT FOR THE UNDERLYING CONDITION?1

See all profiles >

GERD, gastroesophageal reflux disease; UACS, upper airway cough syndrome; NAEB, nonasthmatic eosinophilic bronchitis.

 

PATIENTS WITH CHRONIC COUGH MAY FACE PHYSICAL, PSYCHOLOGICAL, AND SOCIAL HEALTH-RELATED QUALITY OF LIFE (HRQoL) IMPACT3

 
 

Patients with chronic cough may experience dizziness, headaches, physical exhaustion, stress urinary incontinence, and sleep disturbances.12-14

 
 

Patients with chronic cough may experience disruptions in social interactions and recreational activities, and also report feeling embarrassment.12-14

 
 

Chronic cough may be associated with potential speech interruption.12,14

 
 

Patients with chronic cough may experience depressive feelings.15

Explore clinical presentations of patients with chronic cough

References: 1. Irwin RS et al. Chest. 2018;153:196-209. 2. Morice AH et al. Eur Respir J. 2020;55:1901136. 3. Satia I et al. Clin Med (Lond). 2016;16(Suppl 6):S92-S97. 4. Smith JA, Woodcock A. N Engl J Med. 2016;375:1544-1551. 5. Mazzone SB et al. Lancet Respir Med. 2018;6:636-646. 6. Roe NA et al. Curr Otorhinolaryngol Rep. 2019;7:116-128. 7. Song WJ, Chang YS. Clin Transl Allergy. 2015;15:24. 8. Morice AH et al. Eur Respir J. 2014;44:1149-1155. 9. Lee KK et al. Chest. 2021;159:282-293. 10. Kardos P et al. Postgrad Med. Published online April 27, 2021. doi:10.1080/00325481.2021.1914944 11. Sundar KM et al. ERJ Open Res. 2021;7:1-12. 12. Kuzniar TJ et al. Mayo Clin Proc. 2007;82:56-60. 13. Mayo Clinic Staff. Mayo Clinic website. Accessed April 21, 2021. https://www.mayoclinic.org/diseases-conditions/chronic-cough/symptoms-causes/syc-20351575 14. French CL et al. Arch Intern Med. 1998;158:1657-1661. 15. Dicpinigaitis PV et al. Chest. 2006;130:1839-1843.